HPE ProLiant memory compatibility is generation-, model- and configuration-dependent. Every ProLiant generation in this guide uses a different memory architecture, channel layout, or speed ceiling than the one before it, and none of them share compatible memory. This guide explains what each generation supports at the platform level. For a specific system's exact compatible modules and current pricing, use the TekBoost RAM Advisor.
Quick Generation Table
| Generation | Representative models | Memory type | DIMM slots | Maximum memory | Maximum speed | Key notes |
|---|---|---|---|---|---|---|
| Gen9 | DL360, DL380, ML350 Gen9 | DDR4 RDIMM/LRDIMM | 24 | LRDIMM 3 TB; RDIMM 768 GB | Up to 2400 MT/s | NVDIMM only with factory-built E5-2600 v4 systems |
| Gen10 | DL360, DL380, ML350 Gen10 | DDR4 RDIMM/LRDIMM/NVDIMM/HPE Persistent Memory | 24 | LRDIMM 3.0 TB; 6.0 TB w/ Persistent Memory | Up to 2933 MT/s | RDIMM/LRDIMM mixing not supported; speed tied to CPU generation |
| Gen11 | DL360, DL380, ML350 Gen11 | DDR5 RDIMM (+ HBM on select Xeon Max CPUs) | 32 | RDIMM 8.0 TB | Up to 5600 MT/s | No persistent-memory option documented |
No generation in this table shares a memory type, DIMM count, or speed ceiling with another.
Gen9/Gen10/Gen11 Memory Compatibility
HPE Gen9 memory compatibility
Gen9 ProLiant servers (DL360, DL380, ML350 Gen9) use DDR4 RDIMM or LRDIMM (HPE SmartMemory) across 24 DIMM slots (12 per processor, 4 channels per processor, 3 DIMMs per channel), topping out at 3 TB with LRDIMM or 768 GB with RDIMM. Speed depends on the installed DIMM and processor: HPE's own DL360 Gen9 QuickSpecs lists up to 2400 MT/s on E5-2600 v4 processors, dropping as low as 1600 MT/s depending on configuration and processor model, and directs buyers to HPE's online Memory Configuration Tool for the exact combination.
HPE Gen10 memory compatibility
Gen10 ProLiant servers (DL360, DL380, ML350 Gen10) use DDR4 RDIMM, LRDIMM, NVDIMM, or HPE Persistent Memory across 24 DIMM slots (12 per processor, 6 channels per processor, 2 DIMMs per channel). HPE's own documentation ties memory speed directly to CPU generation: DDR4-2933 kits are only supported with 2nd Generation Intel Xeon Scalable processors, while DDR4-2666 kits are only supported with 1st Generation — the same ceiling cannot be assumed across both CPU generations on the same chassis. LRDIMM reaches 3.0 TB; HPE Persistent Memory reaches 6.0 TB on specific 2nd Generation CPU SKUs (Platinum 8200, Gold 6200/5200, and 4215 only).
HPE Gen11 memory compatibility
Gen11 ProLiant servers (DL360, DL380, ML350 Gen11) move to DDR5 RDIMM across 32 DIMM slots (16 per processor, 8 channels per processor, 2 DIMMs per channel), reaching up to 8.0 TB at speeds up to 5600 MT/s — a platform-wide jump from Gen9/Gen10's DDR4. No persistent-memory option is documented for Gen11 in the QuickSpecs reviewed for this guide. Select Intel Xeon Max CPU options add on-package High Bandwidth Memory (HBM), with three documented operating modes (HBM Only, Flat Mode, and Cache Mode), each carrying its own required ratio of system DDR5 memory to HBM capacity — this is a CPU-tier-specific feature, not available on every Gen11 configuration.
RDIMM vs LRDIMM
RDIMM and LRDIMM are both supported on Gen9 and Gen10, with LRDIMM enabling a higher maximum capacity per slot than RDIMM on the same platform — confirmed directly on both generations (Gen9: 3 TB LRDIMM vs 768 GB RDIMM at the same 24-slot count; Gen10: 3.0 TB LRDIMM vs 1.54 TB RDIMM). HPE's own Gen10 QuickSpecs states directly, "Mixing of RDIMM and LRDIMM memory is not supported." Gen11, per the QuickSpecs reviewed for this guide, lists RDIMM only.
Population Rules
HPE's documentation states explicit same-size/same-type mixing restrictions on Gen9 and Gen10, rather than leaving mixing to assumption: Gen9's QuickSpecs states "128GB DIMMs cannot be mixed with any other size DIMMs," and separately that NVDIMMs "cannot be used with LRDIMMs." Gen10's QuickSpecs states the RDIMM/LRDIMM mixing restriction quoted above. Gen11's QuickSpecs documents one SKU-specific restriction — non-3DS 128 GB DIMMs cannot be selected with four named CPU SKUs (4509Y, 4510, 3508U, 4510T). None of the three QuickSpecs documents reviewed for this guide state a generalized channel/bank population order the way some platform-level technical guides do for other product lines; that level of detail lives in HPE's own separate memory population-rules whitepaper, which this guide does not generalize from since it could not be independently verified. Confirm exact population order for a specific model against HPE's own documentation or the RAM Advisor.
Speed Limitations
Installed memory runs at the lower of the DIMM's rated speed and the ceiling the installed processor and population supports. This is confirmed directly on Gen10, where HPE's own documentation ties DDR4-2933 and DDR4-2666 kits to specific CPU generations rather than treating speed as a DIMM-only property, and on Gen9, where HPE states the same memory configuration can run at 2400, 2133, 1866, or 1600 MHz depending on the installed processor. For a specific system, the RAM Advisor separates a module's rated speed from its actual effective speed on that exact configuration.
Dual-Socket Guidance
On dual-socket ProLiant models, memory is populated per processor across all three generations (12 slots/processor on Gen9-10, 16 slots/processor on Gen11), and persistent/high-bandwidth memory figures scale with socket count — Gen11's HBM population requirement explicitly states "duplication of DDR5 system memory is required in two sockets configuration." Confirm the exact per-socket DIMM channel count and population order for a specific model before populating both sockets.
Cross-Generation Compatibility
No memory type in this guide is backward- or forward-compatible with another ProLiant generation. Gen9 and Gen10 both use DDR4, but at different channel counts and generation-specific speed kits (DDR4-2933 vs DDR4-2666) that are themselves tied to the installed CPU generation, not interchangeable within Gen10 either. Only Gen11 uses DDR5. A Gen9 or Gen10 DIMM cannot be used in a Gen11 server, and a DDR4 kit rated for one CPU generation within Gen10 is not guaranteed to run at its rated speed on the other CPU generation in the same chassis family.
Model References
- HPE ProLiant DL360 Gen10 specifications and options
- HPE ProLiant DL380 Gen10 specifications and options
- HPE ProLiant ML350 Gen10 specifications and options
- HPE ProLiant DL360 Gen11 specifications and options
- HPE ProLiant DL380 Gen11 specifications and options
- HPE ProLiant ML350 Gen11 specifications and options
- HPE ProLiant CPU Compatibility Guide
RAM Advisor
This guide covers platform-level memory compatibility by generation. For a model-specific memory configuration, exact compatible modules, and current pricing, use the TekBoost RAM Advisor.
Configure/Shop Options
- Browse refurbished HPE ProLiant servers
- Configure the HPE ProLiant DL360 Gen10
- Configure the HPE ProLiant DL380 Gen10
Hardware bought from TekBoost carries our standard 3-year warranty with Next Business Day part replacement, subject to the terms, exclusions and conditions on that page. Every system is tested before shipment. To confirm an exact memory configuration against current stock, request a quote.
Methodology and sources
Last reviewed: 2026-11-13. Memory type, DIMM count, capacity, and speed figures are drawn directly from HPE's official QuickSpecs for the DL360 Gen9 (c04346229enw), DL360 Gen10 (a00008159enw), DL380 Gen10 (a00008180enw), and DL360 Gen11 (a50004306enw), each read and searched in full for this guide. HPE's separate memory population-rules whitepaper, referenced by URL inside these QuickSpecs, could not be independently fetched from this environment, so this guide does not generalize population order beyond what each QuickSpecs document states directly. HPE marks the Gen9 and Gen10 documents as retired editions for obsolete base products; they are cited here as the authoritative primary source available for direct reference, not presented as current.